Associate Scientist II / III-Genomic Targets Biology

Biogen is dedicated to the discovery and development of innovative therapies for people living with serious neurological and neurodegenerative diseases around the world. We are investing in translational biology, human genomics, and advanced analytics to address scientific questions to support the discovery and development of the next generation of therapeutics.

The Translational Biology Department at Biogen is seeking a bright, skilled, and highly motivated Associate Scientist to join our Genomic Targets Biology team. This highly collaborative and dynamic group is responsible for providing genomic and RNA biology expertise to the R and D organization and specifically, applies discoveries in these disciplines to support Biogens drug discovery research teams and clinical development programs.

This position will provide molecular biology and cell culture support for the Genomic Targets Biology team, with emphasis on defining the RNA biology of our target genes and its relationship to disease. The successful candidate will work both independently and collaboratively to design and execute experiments using sound scientific judgment and will effectively communicate results to supervisors and project teams.

Responsibilities

RNA isoform characterization and quantification from cell- and animal-based models using state of the art technologies, including qPCR, ddPCR and NGS.

Execution of RNA splicing assays, including mini-gene reporter generation and modification.

Perform cell culture and drug treatments to interrogate effects on the transcriptome and proteome.

Deliver experimental results and analyses to supervisors and project teams to help advance novel therapeutic targets.

Maintain constant awareness of novel technologies and adapt new protocols from literature.

Maintain electronic laboratory notebooks, present data to the team, and write study reports.

Proven expertise in molecular and cellular biology techniques, including PCR, gel electrophoresis, protein assays, mammalian cell culture, and modern cloning techniques.

Advanced experience with RNA assay, including qPCR, ddPCR, RACE and RNA immunoprecipitation.

Experience in NGS library preparation (Illumina, PacBio) and CLIP-seq, Ribo-seq, and/or miRNA assay is a plus.

Experience in neuronal cell culture, including primary culture and iPSC-derived neurons is a plus.

Demonstrated ability to work independently but in the context of a team.

Effective at prioritizing responsibilities, and adept at finding solutions for technical challenges.

Strong collaboration, organizational, and communication skills are essential.

Education

AS II- Bachelors and 0-2 years of experience

AS III-Bachelors and 2-4 years of experience or Masters and 0-2 years of experience.

*LI-RD8

All your information will be kept confidential according to EEO guidelines.